Insufficient New Evidence Available On Increased Doses Of Imatinib For Treating GIST
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In swig counselling, promulgated tod, NICE has been ineffectual to commend imatinib (Glivec) at doses of 600 or 800 mg/day for multitude with unresectable and/or metastatic gi stromal tumours (GIST) whose disease has progressed astern discourse with 400 mg/day imatinib.
NICE has antecedently issued direction on the use of imatinib to process GIST, and has recommended imatinib at a acid of 400 mg/day (NICE engineering estimation steering 86). This brushup looks specifically at increased doses of imatinib afterward discourse with 400 mg/day has stopped-up workings. The higher doses existence considered are 600 mg/day and 800 mg/day.
Andrew Dillon, Chief Executive of NICE aforementioned: “NICE already recommends imatinib at a battery-acid of 400 mg/day for patients with gi stromal tumours that cannot be distant by operation. However, since the assessment was promulgated in October 2004, thither has been no new full timber clinical and be effectuality information produced on doses of 600 or 800 mg/day. On this foundation, we cannot urge these higher doses of imatinib for use on the NHS.
“NICE has already recommended sunitinib ( Sutent ) as a handling pick for patients with unresectable or metastatic malignant gi stromal tumours for whom handling with 400 mg/day imatinib handling has not worked or was not suited.”
Draft counsel has been issued for populace interview and the producer and former consultees now bear an chance to see and react to comments made by the freelance Appraisal Committee.
1. For farther entropy purview the assessment.
2. Gastrointestinal stromal tumours (sometimes called gi easygoing weave sarcomas ) are a uncommon form of tumor which predominatly come in the abide or intestine. Many of these tumours are benignant, and those normally campaign few symptoms. If they turn malignant and are jailed to one are of the tum or intestine, they can frequently be distant surgically.
The yearly incidence of GISTs is estimated to be 14.5 per zillion universe which equates to roughly 791 new cases per year in England and Wales (mid-2008 universe). Of these two thirds are considered to be resectable (from the producer’s entry).
3. If a day-by-day superman of 400mg/day were tending for a year, the dose be would be roughly ?19,500 per patient, per year; for 600mg/day some ?29,300 and ?39,067 for 800 mg/day.
4. The modified uncommitted information was ill-used to try and shew the price strength of increased doses of imatinib, and the results bear track the Committee to resolve that increased doses of imatinib are not conquer use of NHS resources.
Source:
View dose data on Sutent .
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